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KMID : 0374019940170040289
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Ewha Medical Journal
1994 Volume.17 No. 4 p.289 ~ p.295
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Study on the Mechanism of the Translocation of Glucose Transporter by Insulin
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Abstract
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Insulin stimulated glucose transport in muscle cell and adipocyte via the rapid redistribution of GLUT4 glucose ransporters from intracellular membrane compartments to the cell surface. The mechanism that insulin triggers the translocation of
glucose
transporters is not known yet whether it is due to the structural differences among glucose transporters or there is a cell specific targetting/translocation apparatus in insulin-sensitive cells.
This study was planned to examine this question by studying insulin effect on the glucose transport rate at adipocyte and hepatocyte fused with GLUT1 vesicle, respectively.
the results showed that treatment of 37 nM insulin increased the transport rate of 3-0methylglucose by 3.8-fold at adipocyte fused with CLUT1 but increased only by 1.4-fold at hepatocyte fused with GLUT1.
Therefore, it is suggested that insulin sensitive cell has a cell-specific targetting/translocation machinery which is triggered by insulin-insulin receptor interaction but insulin sensitivity may not dependent on isoform (structural )-specific
manner.
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